Keywords: microsporidia, immunodeficiency, keratitis, management
AbstractMicrosporidia is an ubiquitous intracellular obligate protozoan parasitic organism which attack both humans and animals. Microsporidia may cause infection in different organs such as eyes, nose, stomach, lungs, kidney, heart, liver and neural system. Microsporidial keratitis is rarely found but its incidence has increased during the last decade especially in patients with AIDS or immunodeficiency state. The purpose of this paper is to provide information on the Microsporidial morphology, ocular clinical manifestation and its management. The method used is a literature study with an explorative descriptive approach that are objective, analytical, and systematic. It can be concluded that Microsporidia is often found in immunodeficiency cases including AIDS. The Microsporidial mode of transmission is most frequently found through air, digestive system, sexual intercourse and direct contact to eyes. Ocular manifestations including conjunctival inflammation and keratitis are mostly found. Microsporidial keratitis identification is performed by cytology and histopathological examination from corneal or conjunctival biopsy. The management of Microsporidial keratitis with topical and systemic therapy are considered as first line therapy but if the therapy fails then surgical management by penetrating keratoplasty can be done.