PATOGENESIS DAN TATALAKSANA PASIEN SEPSIS DENGAN DISSEMINATED INTRAVASCULAR COAGULATION
Keywords: disseminated intravascular coagulation, pathogenesis, sepsis patients with DIC, DIC management
AbstractSepsis is a life-threatening organ dysfunction due to dysregulation of the body's response to infection which is one of the high causes of death in Intensive Care Units. In sepsis, a systemic inflammatory reaction that occurs will activate the coagulation system and increase the consumption of clotting factors, which will cause complications a serious disorder namely coagulopathy, called Disseminated Intravascular Coagulation (DIC). The aim of this study is to summarize the development of new pathogenesis and its impact on the management of DIC in sepsis patients now and in the future. The method used is a quantitative approach. As we know, in 35% of cases of severe sepsis accompanied by DIC, and in cases of sepsis shock, DIC causes high mortality associated with increased disease severity, and seriousness of organ failure with poor outcome. Therefore, it is very important to review the information available in the literature about the approach and management of DIC in sepsis. It can be concluded that DIC is a clinopathological syndrome which is a complication of various diseases characterized by the activation of systemic blood coagulation, intravascular fibrin production, so that it can cause thrombosis of small and medium-sized blood vessels, even can cause organ failure together with platelet consumption and coagulation factors that result in clinical features of bleeding.