• Ferianto Staf bagian Anestesi dan Perawatan Intensif RSUD Dumai/Fellow Konsultan Intensive Care Fakultas Kedokteran Universitas Padjajaran
  • Ezra Oktaliansah Staf Pengajar Konsultan Intensive Care Fakultas Kedokteran Universitas Padjadjaran
  • Indriasari Staf Pengajar Konsultan Intensive Care Fakultas Kedokteran Universitas Padjadjaran


sepsis, sepsis shock, ICU, vasopressors, surviving sepsis campaign (SSC)


Sepsis is a life-threatening organ dysfunction due to dysregulation of the body's response to infection and is one of the main causes of death in the Intensive Care Unit (ICU). The main cause of the high mortality is delay in treatment so that the patient falls into a condition of septic shock. The two main components of treating septic shock are fluid resuscitation and administration of vasopressors. Early administration of vasopressors together with fluids can reduce patient mortality because it reduces the volume of resuscitation and thus prevents fluid overload in the patient. Recent recommendations from the Surviving Sepsis Campaign (SSC) recommend fluid resuscitation and medical therapy within the first 1 hour, which includes administration of vasopressors as early as possible in cases of life-threatening hypotension, concurrently or immediately after fluid resuscitation to maintain MAP levels ≥ 65mmHg. Holistic treatment will reduce the mortality of patients with septic shock in the ICU. The aim of this study was to treat sepsis patients as early as possible. The method used is based on the reduction in mortality or success in the treatment of septic shock patients who are given Norepinephrine (NEP) at the start to achieve the mean arterial pressure (MAP) and desired lactate clearance. It can be concluded that most patients with septic shock require early administration of vasopressors. for hemodynamic stabilization, in addition to appropriate fluid resuscitation. The administration of vasopressor drugs is very important in achieving hemodynamic resuscitation targets which aim to increase oxygen delivery through increased cardiac output, perfusion of vital organ blood flow and organ perfusion pressure.


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